Human antibodies to SARS-CoV2 for the prophylaxis and therapy of COVID-19 (CoVER-Ab)
- Funded by Bundesministerium für Bildung und Forschung [German Federal Ministry of Education and Research] (BMBF)
- Total publications:0 publications
Grant number: 01KI2043B
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Key facts
Disease
COVID-19Start & end year
20202021Known Financial Commitments (USD)
$78,624.32Funder
Bundesministerium für Bildung und Forschung [German Federal Ministry of Education and Research] (BMBF)Principal Investigator
PendingResearch Location
GermanyLead Research Institution
Fraunhofer Institut für Zelltherapie und Immunologie LeipzigResearch Priority Alignment
N/A
Research Category
Therapeutics research, development and implementation
Research Subcategory
Pre-clinical studies
Special Interest Tags
N/A
Study Type
Non-Clinical
Clinical Trial Details
N/A
Broad Policy Alignment
Pending
Age Group
Unspecified
Vulnerable Population
Unspecified
Occupations of Interest
Unspecified
Abstract
Given the urgent need for prophylaxis and therapy of severe CoVID-19 the project aims to rapidly identify neutralizing human antibodies (nAb) against SARS-CoV2. Antibodies will be derived from immunoglobulin heavy and light chain pairs of plasmablasts of reconvalescent CoVID-19 patients and from immunized mice, that are transgenic for the human immunoglobulin repertoire. Antibodies will be screened for binding to the S protein of SARS-CoV2 and selected based on their efficacy in SARS-CoV2 neutralization assays. Selected nAbs will be tested for efficacy and potential disease enhancement in a mouse model for pre- and post-exposure prophylaxis and in a pre-exposure non-human primate model. Partnerships for parallel clinical development will be formed as soon as the first nAb has been identified.