Domestic animals as potential vectors for SARS-CoV-2 transmission
- Funded by Bundesministerium für Bildung und Forschung [German Federal Ministry of Education and Research] (BMBF)
- Total publications:1 publications
Grant number: 01KI2074B
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Key facts
Disease
COVID-19Start & end year
20202021Known Financial Commitments (USD)
$109,423.92Funder
Bundesministerium für Bildung und Forschung [German Federal Ministry of Education and Research] (BMBF)Principal Investigator
PendingResearch Location
GermanyLead Research Institution
Stiftung Tierärztliche Hochschule HannoverResearch Priority Alignment
N/A
Research Category
Animal and environmental research and research on diseases vectors
Research Subcategory
Animal source and routes of transmission
Special Interest Tags
N/A
Study Type
Non-Clinical
Clinical Trial Details
N/A
Broad Policy Alignment
Pending
Age Group
Not Applicable
Vulnerable Population
Not applicable
Occupations of Interest
Not applicable
Abstract
Abstract: "The recent emergence and the rapid pandemic spread of SARS-CoV-2 pose a global health emergency. The origin of the virus has not been fully investigated so far. It is assumed that horseshoe bats harboring progeny coronaviruses serve as the natural reservoir host, while pangolins may serve as intermediate host. However, information on potential permissive animal species is largely lacking. Given the frequent and close contact between humans and domestic animals, is it important to elucidate whether animals such as dogs, cats or ferrets and livestock, especially cattle and pigs, are susceptible to SARS-CoV-2 infection and might promote viral dissemination among animals and humans. Indeed, there is already circumstantial evidence that dogs might become infected by SARS-CoV-2. Therefore, this project will employ primary cells obtained from the upper and lower respiratory tract of a variety of domestic animals to determine permissiveness to SARS-CoV-2 infection. Studies will include mode of entry and spread and pathogenetic mechanisms using molecular and microscopic analyses. The results will facilitate risk assessment and prevention of potential interspecies transmission."; Research Type: discovery; Study population: domestic animals (cats, dogs) and farm animals (bovine animals, pigs)
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