Functional and dysfunctional human CD4 T cell and B cell responses to bacteria and viruses
- Funded by National Institutes of Health (NIH)
- Total publications:0 publications
Grant number: 3U19AI142742-02S1
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Key facts
Disease
COVID-19Start & end year
20202021Known Financial Commitments (USD)
$982,950Funder
National Institutes of Health (NIH)Principal Investigator
PendingResearch Location
United States of AmericaLead Research Institution
LA JOLLA INSTITUTE FOR IMMUNOLOGYResearch Priority Alignment
N/A
Research Category
Pathogen: natural history, transmission and diagnostics
Research Subcategory
Immunity
Special Interest Tags
N/A
Study Type
Clinical
Clinical Trial Details
Unspecified
Broad Policy Alignment
Pending
Age Group
Unspecified
Vulnerable Population
Unspecified
Occupations of Interest
Unspecified
Abstract
PROJECT SUMMARYOverall ComponentCOVID19 is a severe ongoing pandemic. Our understanding of the immune response to this disease is lacking,which impairs both the development of proper therapeutics and a vaccine. Vaccines are one of the most costeffective and extraordinarily successful medical interventions. Most of those vaccines depend on CD4 T+ cellsand their help to B cells. We have developed multiple new techniques to study human CD4+ T cells over the pastseveral years, which have have been implementing in our LJI CCHI. The supplement proposed here will facilitaterapid and vigorous pursuit of an understanding of the T cell responses to SARS-CoV2 in humans, which mayhelp in the development of treatments and vaccines for COVID19.