Epidémiolgie - Santé Publique (Epidemiology - Public Health) - Evaluation d'une stratégie de dépistage du SARS-CoV-2 en routine chez le personnel et les femmes accouchant à la maternité du CHU Yalgado Ouédraogo, Ouagadougou, Burkina Faso : acceptabilité, prévalence et devenir du couple mère-enfant à six semaines. Assessment of a routine screening strategy of SARS-CoV-2 in health professionals and delivering women at the maternity hospital of Y. Ouedraogo Hospital, Ouagadougou, Burkina Faso: acceptability, prevalence and six-week outcomes of the mother-child pair.

Burkina Faso was one of the first countries in West African to report cases of SARS-CoV-2 infection. As the epidemic becomes more generalized, healthcare workers and pregnant women are being affected as much as the rest of the population. Knowledge on the coronavirus is limited in Africa, and pregnant women are a useful sentinel population in epidemic surveillance. In this context, we find a unique opportunity to implement and evaluate operational research in a maternity ward, reinforcing the protection of healthcare workers, as a priority, and evaluating a routine screening strategy for SARS-CoV-2 infections in healthcare workers, and parturient women. Objective: Main objective: To implement and evaluate a routine screening strategy for SARS-CoV-2 infection with triage of healthcare workers and parturient women at the Yalgado Ouédraogo University Hospital maternity ward, in Ouagadougou in Burkina Faso, - to measure the epidemiological indicators (prevalence and incidence) of the infection and its impact on short-term mother-infant health outcomes (morbi-mortality, birth and pregnancy outcomes and mother-to-child transmissions). Intervention : This intervention will take place over a 6-month period and allow building and exhaustive prospective cohort with 6 weeks of follow-up of mother-infant pairs Site : Yalgado Ouédraogo University Hospital maternity ward, Ouagadougou, Burkina Faso Study design: Cross-sectional study including a SARS-CoV-2 diagnostic test by rt-PCR to all healthcare workers, and to parturient women presenting symptoms in line with probable COVID-19 cases, followed by an observational prospective cohort comprised of delivering women at the Yalgado Ouédraogo University Hospital maternity ward and followed-up with their newborn until 6 weeks post-partum, and according to their exposure to SARS-CoV-2. Inclusion criteria: All healthcare workers working in Yalgado Ouédraogo University Hospital maternity ward at the time of implementation of the study, who give informed consent; all parturient women in the maternity ward from July 1st to December 31st 2020, who give informed consent and live in Ouagadougou with their newborn. Evaluation criteria : -Acceptability of SARS-CoV-2 screening at birth - Prevalence of active SARS-CoV-2 infection, and past infection with acquired immunity at birth - Morbidity, maternal mortality and immediate and 6-week post-partum complications - Birth outcome complications: low birth weight, prematurity, microcephaly, stillbirths, birth defects - Early and late-run neonatal mortality - Estimate of SARS-CoV-2 mother-to-child-transmission at birth at 6-week postnatal - SARS-CoV-2 infection and its consequences, preventive measures and screening knowledge, attitude and practice and perceptions - Acceptability of SARS-CoV-2 diagnosis by RT-PCR among healthcare workers in the maternity and pediatric wards and associated factors. Size: 200 healthcare workers and 3150 mother-infants pairs at birth, of whom 1225 possible cases requiring diagnosis