Cardiovascular response in COVID-19
- Funded by UK Research and Innovation (UKRI)
- Total publications:0 publications
Grant number: C19-IUC-082
Grant search
Key facts
Disease
COVID-19Funder
UK Research and Innovation (UKRI)Principal Investigator
PendingResearch Location
United KingdomLead Research Institution
Wellcome - Medical Research Council Cambridge Stem Cell InstituteResearch Priority Alignment
N/A
Research Category
Pathogen: natural history, transmission and diagnostics
Research Subcategory
Pathogen morphology, shedding & natural history
Special Interest Tags
N/A
Study Type
Non-Clinical
Clinical Trial Details
N/A
Broad Policy Alignment
Pending
Age Group
Not Applicable
Vulnerable Population
Not applicable
Occupations of Interest
Not applicable
Abstract
Cardiovascular dysfunction in COVID-19 will be investigated in vitro using human embryonic stem cell derived-cardiomyocyte and vascular cell models. Examining viral proteins and pseudotypes in to human cardiomyocytes and vascular cells and ways this can be modulated by modifying the ACE2 viral receptor or accessory proteases such as TMPRSS2. The project will also study the effects of the immune response on these cells.