Mathematical modeling and adaptive control to inform real time decision making for the COVID-19 pandemic at the local, regional and national scale
- Funded by Department of Health and Social Care / National Institute for Health and Care Research (DHSC-NIHR), UK Research and Innovation (UKRI)
- Total publications:24 publications
Grant number: MR/V009761/1
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Key facts
Disease
COVID-19Start & end year
20202021Known Financial Commitments (USD)
$149,161.48Funder
Department of Health and Social Care / National Institute for Health and Care Research (DHSC-NIHR), UK Research and Innovation (UKRI)Principal Investigator
PendingResearch Location
United KingdomLead Research Institution
University of WarwickResearch Priority Alignment
N/A
Research Category
Epidemiological studies
Research Subcategory
Disease transmission dynamics
Special Interest Tags
N/A
Study Type
Non-Clinical
Clinical Trial Details
N/A
Broad Policy Alignment
Pending
Age Group
Not Applicable
Vulnerable Population
Not applicable
Occupations of Interest
Not applicable
Abstract
Emergence of a novel strain of coronavirus in the city of Wuhan in China resulted in a global pandemic and the implementation of social distancing measures in a significant number of countries around the world in order to reduce the risk to the most vulnerable members of society. The first case of infection in the UK was reported on 31st January 2020 and with cases continuing to rise, the country was put into lockdown on 23rd March in an effort to reduce the spread of disease.Throughout the epidemic in the UK, mathematical models (including predictions from Warwick) have been used to provide support to the government and to guide decision making. However, these models are typically required to repeatedly produce new outputs as more data emerges on a daily basis on cases and deaths, and there is a need to investigate how the predictions are likely to change as more data become available.This project will develop methodology that will allow for robust parameter inference of the Warwick model, which is already being used for UK-decision support. We will enhance our real time model fitting, incorporating up to date information on cases and outcomes, and use this framework to determine multi-phase adaptive control policies, with a focus upon optimal timing of relaxation and tightening of social distancing measures, that should be implemented to mitigate future infection waves. Our results will be communicated directly to the scientific pandemic influenza modelling group that advises the UK government.