Sex as a Biological Variable Supplement - Animal models for SARS-CoV-2: vaccines and immune enhancement
- Funded by Canadian Institutes of Health Research (CIHR)
- Total publications:0 publications
Grant number: Supplement to P00053
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Key facts
Disease
COVID-19Start & end year
20202021Known Financial Commitments (USD)
$37,500Funder
Canadian Institutes of Health Research (CIHR)Principal Investigator
PendingResearch Location
CanadaLead Research Institution
University of SaskatchewanResearch Priority Alignment
N/A
Research Category
Pathogen: natural history, transmission and diagnostics
Research Subcategory
Disease models
Special Interest Tags
N/A
Study Type
Non-Clinical
Clinical Trial Details
N/A
Broad Policy Alignment
Pending
Age Group
Not Applicable
Vulnerable Population
Not applicable
Occupations of Interest
Not applicable
Abstract
In December 2019 a novel coronavirus (CoV) was identified as the cause of pneumonia in a cluster of patients in Wuhan, China. This virus is related to severe acute respiratory syndrome (SARS)-CoV and has been named SARS-CoV-2. In less than two months, there have been over 69,000 cases and over 1600 deaths. Quarantine measures have been imposed on entire cities in China in an attempt to control spread. Cases of SARS-CoV-2 have been identified in 28 other countries and there is concern that this could lead to global pandemic. Here we propose to identify what common lab and agricultural animals may be infected with SARS-CoV-2. This addresses two important questions. What animals can be infected and may pose a risk (or are at risk) and can these animals be used to models. Animal model allow us to understand how the virus causes disease, whether vaccines can be developed that protect from disease and how might the virus be transmitted. These are critical questions that need to be addressed when a new pathogen emerges. In addition, there is some concern that less than optimal vaccines or previous exposure to related pathogens could exaserbate disease - this is a somewhat unique phenomenom that was observed with SARS-CoV vaccines. We plan to investigate whether these animal models can be used to test for this, to ensure that vaccines are safe prior to testing in human clinical trials