Identifying pathogenesis of COVID-19 pathology in the Dutch population and unravelling differences in pathogenetic mechanisms in high- and low-risk groups
- Funded by Netherlands Organisation for Health Research and Development (ZonMW)
- Total publications:0 publications
Grant number: 1.043E+13
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Key facts
Disease
COVID-19Start & end year
20202022Known Financial Commitments (USD)
$526,491.36Funder
Netherlands Organisation for Health Research and Development (ZonMW)Principal Investigator
PendingResearch Location
NetherlandsLead Research Institution
Erasmus Medical CenterResearch Priority Alignment
N/A
Research Category
Clinical characterisation and management
Research Subcategory
Disease pathogenesis
Special Interest Tags
N/A
Study Type
Clinical
Clinical Trial Details
Not applicable
Broad Policy Alignment
Pending
Age Group
Unspecified
Vulnerable Population
Unspecified
Occupations of Interest
Unspecified
Abstract
Project description COVID-19 has a striking variation in disease severity between patients. There is so far insufficient knowledge about which processes in the tissue are the cause of this variation. This limits the development of targeted diagnostics and therapy for individual patients. Tissue studies in COVID-19 patients may change this, as the tissue can distinguish between direct virus-induced damage, out-of-control inflammation, increased coagulation, and scarring, all of which may require different treatment. need. Research and expected outcomes Within the framework of this project, the tissue available and suitable in the Netherlands from both deceased and living COVID-19 patients will be collected to be able to ask and answer these questions. The results are expected to lead to improved understanding of the variability of this disease and lead to more personalized treatment.