Obesity as an amplifier of inflammation and organ injury in SARS-CoV-2 infected patients: prognostic potential and therapeutic target Thema 3: Risicoanalyse en prognostiek
- Funded by Netherlands Organisation for Health Research and Development (ZonMW)
- Total publications:0 publications
Grant number: 1.043E+13
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Key facts
Disease
COVID-19Start & end year
20202022Known Financial Commitments (USD)
$502,281.54Funder
Netherlands Organisation for Health Research and Development (ZonMW)Principal Investigator
PendingResearch Location
NetherlandsLead Research Institution
University Medical Center GroningenResearch Priority Alignment
N/A
Research Category
Clinical characterisation and management
Research Subcategory
Prognostic factors for disease severity
Special Interest Tags
N/A
Study Type
Clinical
Clinical Trial Details
Not applicable
Broad Policy Alignment
Pending
Age Group
Unspecified
Vulnerable Population
Other
Occupations of Interest
Unspecified
Abstract
Project description Recent research shows that 77% of the COVID-19 patients who were treated in a Dutch Intensive Care Unit (IC) were overweight. There is some evidence that there is a positive correlation between obesity and the severity of COVID-19. Why overweight people often come to the ICU with severe symptoms of COVID-19 is not yet known. Research and expected outcomes This study investigates the underlying molecular mechanisms behind the reinforcing role of excess adipose tissue on the response of the COVID-19 patient. It is investigated exactly how excess adipose tissue contributes to the development of organ failure, especially failing lungs and kidneys. Once these mechanisms behind COVID-19-mediated organ failure are understood, new drug therapies can be developed to combat organ failure.