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Evaluating the determinants of coronavirus tropism in 3D models of human pulmonary epithelia (TROPICORO project - TROPIsm of COROnaviruses)

  • Funded by Institut Pasteur International Network (IPIN)
  • Total publications:219 publications

Grant number: Unknown

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Key facts

  • Disease

    COVID-19

  • Funder

    Institut Pasteur International Network (IPIN)

  • Principal Investigator

    Pending

  • Research Location

    N/A

  • Lead Research Institution

    N/A

  • Research Priority Alignment

    N/A

  • Research Category

    Pathogen: natural history, transmission and diagnostics

  • Research Subcategory

    Pathogen morphology, shedding & natural history

  • Special Interest Tags

    N/A

  • Study Type

    Non-Clinical

  • Clinical Trial Details

    N/A

  • Broad Policy Alignment

    Pending

  • Age Group

    Not Applicable

  • Vulnerable Population

    Not applicable

  • Occupations of Interest

    Not applicable

Abstract

This study will compare the tropism of SARS-CoV-2 and more benign human coronaviruses for primary epithelia of the respiratory tract, to determine whether tropism associates with pathogenicity. The research team will use models based on reconstructed human airway epithelia and take advantage of a lung-on-chip technology that mimics the pulmonary alveolae stretch associated with breathing to develop physiologically relevant models of SARS-CoV-2 infection.

Publicationslinked via Europe PMC

Last Updated:a day ago

View all publications at Europe PMC

Newborn Screening for Spinal Muscular Atrophy: Variations in Practice and Early Management of Infants with Spinal Muscular Atrophy in the United States.

QTc Interval Prolongation as an Adverse Event of Azole Antifungal Drugs: Case Report and Literature Review.

Systematic Review and Meta-Analysis of Particle Beam Therapy versus Photon Radiotherapy for Skull Base Chordoma: TRP-Chordoma 2024.

Ciprofloxacin Concentrations 100-Fold Lower than the MIC Can Select for Ciprofloxacin Resistance in Neisseria subflava: An In Vitro Study.

Neonatal Physical Growth Predicts Electroencephalography Power in Rural South African Children.

A Systematic Review of Extracellular Matrix-Related Alterations in Parkinson's Disease.

Medicine Non-Adherence: A New Viewpoint on Adherence Arising from Research Focused on Sub-Saharan Africa.

In Situ Assessment of Uplink Duty Cycles for 4G and 5G Wireless Communications.

Genomic Engineering of Oral Keratinocytes to Establish In Vitro Oral Potentially Malignant Disease Models as a Platform for Treatment Investigation.