Monitoring the evolution, spread and transmission of SARS-CoV-2 through whole genome sequencing to enable fast genotype to phenotype prediction
- Funded by Netherlands Organisation for Health Research and Development (ZonMW)
- Total publications:0 publications
Grant number: 1.01501E+13
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Key facts
Disease
COVID-19Start & end year
20202021Known Financial Commitments (USD)
$483,823.6Funder
Netherlands Organisation for Health Research and Development (ZonMW)Principal Investigator
PendingResearch Location
NetherlandsLead Research Institution
Erasmus Medical CentreResearch Priority Alignment
N/A
Research Category
Pathogen: natural history, transmission and diagnostics
Research Subcategory
Pathogen genomics, mutations and adaptations
Special Interest Tags
N/A
Study Type
Non-Clinical
Clinical Trial Details
N/A
Broad Policy Alignment
Pending
Age Group
Not Applicable
Vulnerable Population
Not applicable
Occupations of Interest
Not applicable
Abstract
Emerging viral infections, once established in the human population, may evolve with continued circulation. The evolution of SARS-CoV-2 in the Netherlands will be monitored throughout the phases of the pandemic with close to real-time whole genome sequencing, allowing fast responses in case of remarkable genomic changes, and providing a reference database for investigation of community outbreaks. Bioinformatic tools will be developed to rapidly identify changes that may impact ability to detect, treat and prevent infections. In case novel lineages start to emerge, the effects on transmission dynamics will be further investigated using in vitro and in vivo studies to specifically look at the receptor binding properties, pathogenicity and other relevant virus properties. The results will directly inform precise public health decision making to control the outbreak.