Accelerated artificial intelligence strategy for drug repositioning against COVID-19
- Funded by Fundação de Amparo à Pesquisa do Estado de São Paulo [São Paulo Research Foundation] (FAPESP)
- Total publications:5 publications
Grant number: 2020/05369-6
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Key facts
Disease
COVID-19Start & end year
20202022Known Financial Commitments (USD)
$32,846.07Funder
Fundação de Amparo à Pesquisa do Estado de São Paulo [São Paulo Research Foundation] (FAPESP)Principal Investigator
PendingResearch Location
BrazilLead Research Institution
Universidade Estadual de CampinasResearch Priority Alignment
N/A
Research Category
Clinical characterisation and management
Research Subcategory
Disease pathogenesis
Special Interest Tags
Digital Health
Study Type
Non-Clinical
Clinical Trial Details
N/A
Broad Policy Alignment
Pending
Age Group
Not Applicable
Vulnerable Population
Not applicable
Occupations of Interest
Not applicable
Abstract
The arrival of COVID-19 in Brazil in March 2020, with its rapid spread, exponential growth of cases worldwide and the high lethality of infected patients, has generated panic in the population, disrupted public and private health systems and impacted negative way in the economy of Brazil and the world. Although the search for an effective vaccine is the first arrival of COVID-19 in Brazil in March 2020, with its rapid spread, exponential growth of cases worldwide and the high lethality of infected patients, it has generated panic in the population, disrupted systems public and private health and negatively impacted the economy of Brazil and the world. Although the search for an effective vaccine is urgent, its development should take at least a year and a half before approval. Thus, the need to discover a treatment that can be quickly approved for use in infected patients becomes evident. Drug repositioning offers a potentially faster approach to identifying drugs already approved for use in humans. Artificial intelligence (AI) is a frontier area of knowledge that allows the identification of potentially active compounds with appropriate pharmacokinetic and toxicological properties, leading to greater speed, greater success rate and lower cost in the discovery of new drugs. In this context, in order to transform drug discovery from a slow, sequential and high-risk process to a fast, integrated model with reduced risk of failure, this project aims to develop an integrated platform based on artificial intelligence for accelerate the repositioning of drugs already approved for use in humans for the treatment of COVID-19 with the potential for rapid clinical development, through the integration of high performance computing with chemical and biological data and the use of emerging biotechnological and experimental technologies. development should require at least a year and a half before approval. Thus, the need to discover a treatment that can be quickly approved for use in infected patients becomes evident. For this, we add different expertise from researchers at the Biology Institute of UNICAMP and other research institutions in Brazil and abroad and we will use a multidisciplinary approach that will involve the development and application of artificial intelligence tools to guide and accelerate the repositioning of drugs in use based on inhibiting virus entry into the host cell by inhibiting the interaction between viral Spike proteins and human ACE-2 and testing antiviral activity in cell culture in a level 3 biological containment laboratory. As preliminary data, in a accepted for publication, researchers involved in this proposal developed computational models and performed a virtual screening based on docking of all drugs approved by the FDA (~ 2,400 drugs) in viral glycoprotein spike complexed with human protein ACE2, with the grid centered on the interface of the two proteins. After docking, drugs were reordered using machine learning models developed using the Bayesian algorithm and ECFP6 fingerprint descriptors for SARS-CoV phenotypic data. At the end of this approach, 25 approved drugs were selected and will be subjected to in vitro tests against SARS-CoV-2 in Vero cells.
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